Abstract
Effects of embryonic exposure to aflatoxin-B 1 (AFB 1) on the postnatal development of chicken mononuclear phagocytic system function was examined. Single exposure of 6-d chick embryos to 0.1, 0.5, and 1 μg AFB 1 in 10 μL acetone was employed. Control embryos received 10 μl solvent and sham-treated controls included embryos with a hole in the egg shell with no compound added. Aflatoxin B 1 exposure caused a dose-related increase in embryonic mortality. After hatch, no differences were observed in body weight gain among treatment groups. The incidence of circulating thrombocytes was reduced in chicks exposed to the highest AFB 1 dose with enhancement in monocyte and lymphocyte cell populations. Birds exposed to 1 μg AFB 1 recruited fewer macrophages in the peritoneal cavity after i.p. Sephadex elicitation along with reduced substrate adherence potential of peritoneal exudate cells. Similarly, macrophages from 0.5 and 1 μg AFB 1-treated birds had depressed phagocytic potential. These results suggest that long-term immune depression of macrophage-mediated functions can occur following embryonic exposure to AFB 1.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
