Abstract
Background: Scientific literature suggests that different types of training can have different effects on secretion of irisin and myostatin.Objectives: The purpose of this study was to determine the effect of resistance exercise training (RET), aerobic exercise training (AET) and concurrent (aerobic + resistance) exercise training (CET) on serum irisin and myostatin in untrained women.Methods: Thirty-five non-obese, untrained women were randomly assigned to control (n = 6, age 25.50 ± 4.80 years), RET (n = 10, age 24.60 ± 2.45 years), AET (n = 9, age 24.66 ± 2.29 years) or CET (n = 10, age 26.60 ± 4.00 years) groups. Subjects in training groups trained for 8 weeks, three times per week. The levels of serum irisin, myostatin were measured before and after the training period. Results: It was found that the CET group had significantly reduced serum irisin (p = .028) and myostatin (p = .005) concentrations. The myostatin concentration was also significantly decreased in the RET group (p = .008). Conclusion: CET, AET or RET were not effective for improving (increase) irisin circulating level. In addition, RET and CET were more effective than AET in reducing circulating myostatin levels.
Highlights
Skeletal muscle has recently been recognized as an endocrine organ that produces and releases various cytokines termed myokines (Karsenty & Olson, 2016) that are involved in the regulation of several physiological and metabolic pathways
There were no significant differences in waist circumference, hip circumference and waist to hip ratio (WHR) for resistance exercise training (RET), aerobic exercise training (AET), CET and control group
Results showed that RET and AET have no effect on serum irisin in previously untrained young women
Summary
Skeletal muscle has recently been recognized as an endocrine organ that produces and releases various cytokines termed myokines (Karsenty & Olson, 2016) that are involved in the regulation of several physiological and metabolic pathways. Skeletal muscle secretes other hormones such myostatin, a member of the transforming growth factor β superfamily, which is a critical factor in regulating irisin. It has been shown, irisin treatment significantly decreased myostatin gene expression in human myocytes (Huh, Dincer, Mesfum, & Mantzoros, 2014). Results: It was found that the CET group had significantly reduced serum irisin (p = .028) and myostatin (p = .005) concentrations. Conclusion: CET, AET or RET were not effective for improving (increase) irisin circulating level. RET and CET were more effective than AET in reducing circulating myostatin levels
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