Abstract
Serum nitrite and nitrate levels were determined in 34 epileptic children treated with valproic acid and 23 with carbamazepine and compared to 38 non-active epileptic children with no antiepileptic drug therapy, in a study at KSU Medical School, Turkey.
Highlights
Twenty-two children with cerebral infarction on neonatal MRJ were examined neurologically at school age in a study at Imperial College School of Medicine, Hammersmith, London, UK
Lanthier et al found no difference in recurrence rates between the anticardiolipin antibody-positive and aCL-negative groups, when 185 children with a first arterial ischemic stroke or TIA were followed for a median of 3 years
Serum nitrite and nitrate levels were determined in 34 epileptic children treated with valproic acid and 23 with carbamazepine and compared to 38 non-active epileptic children
Summary
Twenty-two children with cerebral infarction on neonatal MRJ were examined neurologically at school age in a study at Imperial College School of Medicine, Hammersmith, London, UK. In children suffering a neonatal cerebral infarction, signs of neuromotor impairment become more obvious at school age when the neurologic examination is more structured. Lanthier et al found no difference in recurrence rates between the anticardiolipin antibody (aCL)-positive and aCL-negative groups, when 185 children with a first arterial ischemic stroke or TIA were followed for a median of 3 years. In the absence of a prospective randomized trial, screening for antiphospholipid syndrome (APS) should continue as a routine component of the evaluation of arterial ischemic stroke and risk of recurrence. Subsequent publication of the results of the antiphospholipid antibodies and stroke study (APASS), a prospective double-blind cohort study involving 1770 participants from multiple US clinical sites (JAMA Feb 4, 2004;291:576-584), concludes that the presence of aCL in patients with ischemic stroke does not predict an increased risk of subsequent stroke.
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