Abstract
In the present study, intraperitoneal (IP) administration of the dopaminergic receptor agonist apomorphine (0.1, 0.25, and 0.5 mg/kg) induced a dose-dependent licking in rats. The intraperitoneal injection of the α 1‴adrenoceptor agonist phenylephrine (1–8 mg/kg) but not the α 2-adrenoceptor agonist clonidine (0.025–0.05 mg/kg) decreased licking induced by apomorphine. The α-adrenoceptor antagonists prazosin, phenoxybenzamine, and yohimbine also reduced the apomorphine response significantly. The response induced by phenylephrine was decreased by a dose of prazosin. The β 1-adrenenocepor agonist dobutamine and β 2-adrenenocepor agonist salbutamol did not alter the apomorphine response. However, β 2-adrenenocepor antagonists atenolol and propranolol reduced the apomorphine effect. It may be concluded that α 1- and possibly β 1-adrenoceptor mechanisms may be involved in modulation of licking behavior.
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