Effects of ADIPOQ polymorphisms on PCOS risk: a meta-analysis

Zhengling Liu,Zengyan Wang,Jingjing Fu,Yonghui Tian,Changhong Hao

doi:10.1186/s12958-018-0439-6

Zhengling Liu, Zengyan Wang + Show 3 more

Open Access

https://doi.org/10.1186/s12958-018-0439-6

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Abstract

BackgroundWhether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial. Therefore, we performed this study to better explore correlations between ADIPOQ polymorphisms and PCOS risk.MethodsLiterature retrieve was conducted in PubMed, Medline and Embase. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated.ResultsEighteen studies were enrolled for analyses. Pooled overall analyses showed that rs1501299 polymorphism was significantly associated with PCOS risk (recessive model: p = 0.02, OR = 0.77, 95%CI 0.62–0.95; allele model: p = 0.001, OR = 1.15, 95%CI 1.06–1.26). Further subgroup analyses according to ethnicity of participants revealed that rs1501299 and rs2241766 polymorphisms were both significantly correlated with PCOS risk in Caucasians. In addition, rs1501299 polymorphism was also significantly correlated with PCOS risk in East Asians.ConclusionsOur findings indicated that rs1501299 and rs2241766 polymorphisms might serve as genetic biomarkers of PCOS in certain ethnicities.

Highlights

Whether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial
Overall and subgroup analyses To investigate potential correlations between ADIPOQ polymorphisms and PCOS risk, fifteen studies about rs1501299 polymorphism and seventeen studies about rs2241766 polymorphism were included for pooled analyses
A significant association with PCOS risk was detected for rs1501299 polymorphism in overall analyses

Summary

Introduction

Whether adiponectin (ADIPOQ) polymorphisms are associated with the risk of polycystic ovary syndrome (PCOS) remain controversial. Adiponectin (ADIPOQ), a multifunctional adipocytokine that is primarily secreted by adipocytes, plays a pivotal role in regulating energy and material metabolism [9]. Previous studies showed that expression level of adiponectin was significantly reduced in patients with various metabolic disorders such as diabetes, obesity and insulin resistance, which suggested that adipoenctin might be involved in the pathogenesis of above-mentioned diseases [10, 11]. Considering the metabolic nature of PCOS and the fact that the expression levels of adiponectin and its receptors in female reproductive organs (ovary and uterus) vary in different phases of oestrous cycle [12], it is biologically plausible that adiponectin might be implicated in the occurrence and development of PCOS

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