Abstract
BackgroundTo investigate the effects of adiponectin (ADPN), plasma D-dimer (D-D), inflammation, and tumour markers on clinical characteristics and prognosis of patients with ovarian cancer.MethodsA total of 80 patients with ovarian cancer treated in our hospital from April 2017 to November 2019 were enrolled as study subjects and evenly divided into an observation group (patients with ovarian cancer) and a control group (patients with the benign ovarian tumour) based on the results of the postoperative pathological biopsy. The levels of ADPN, plasma D-D, inflammatory factors, and serum tumour markers carbohydrate antigen 125 (CA125), human epididymis protein 4 (HE4), and risk of ovarian malignancy algorithm (ROMA) were compared between the two groups. The diagnostic value of serum tumour markers CA125, HE4, and ROMA in ovarian cancer was explored. The correlations of ROMA changes with the changes in the levels of ADPN, plasma D-D, high-sensitivity C-reactive protein (hs-CRP), CA125, and HE4 were analysed. Additionally, the related risk factors affecting the development of ovarian cancer were subjected to univariate and multivariate logistic regression analyses.ResultsIn comparison with the control group, the observation group exhibited a lowered ADPN level (p<0.05), notably raised levels of plasma D-D, inflammatory factors hs-CRP and interleukin-6 (IL-6) and serum tumour markers CA125 and HE4 and an evidently increased ROMA (p<0.05). Besides, the detection of serum ROMA showed the highest specificity and sensitivity and low false-positive rate and false-negative rate. The changes of ROMA were positively correlated with the changes in the levels of plasma D-D, hs-CRP, CA125, and HE4 (p<0.05) and negatively associated with the changes in ADPN level (p<0.05). The results of the univariate analysis showed that abnormal ADPN, D-D, hs-CRP, IL-6, CA125, and HE4 levels were related to risk factors affecting the development of ovarian cancer. It was found through multivariate logistic regression analysis that decreased ADPN level and increased D-D, hsCRP, IL-6, CA125, and HE4 levels were independent risk factors affecting the development of ovarian cancer.ConclusionsIn the case of ovarian cancer, the ADPN level declines, while the levels of plasma D-D, inflammatory factors, and serum tumour markers CA125, HE4, and ROMA rise obviously. Besides, the ROMA level displays a positive relation to the content of CA125, HE4, plasma D-D, and inflammatory factors and a negative association with the ADPN level.
Highlights
Patients with ovarian cancer tend to be at the middle or advanced stage when definitely diagnosed, and some of them even lost the opportunities for surgery (1)
Studies have manifested that the 5-year survival rate of patients with early ovarian cancer is more than 90% after regular treatment (4), and that of those with middle or advanced ovarian cancer, especially those who have lost opportunities for surgical treatment, is less than 20% (5)
Before surgery, fasting elbow venous blood was collected from patients in the morning for examinations of ADPN, plasma D-D, inflammatory factors [high-sensitivity C-reactive protein and interleukin-6 (IL6)] and tumor markers [carbohydrate antigen 125 (CA125), human epididymis protein 4 (HE4) and risk of ovarian malignancy algorithm (ROMA)]
Summary
Patients with ovarian cancer tend to be at the middle or advanced stage when definitely diagnosed, and some of them even lost the opportunities for surgery (1). Studies have manifested that the 5-year survival rate of patients with early ovarian cancer is more than 90% after regular treatment (4), and that of those with middle or advanced ovarian cancer, especially those who have lost opportunities for surgical treatment, is less than 20% (5). The effects of ADPN, plasma D-D, inflammation, and tumour markers on the prognosis of ovarian cancer were explored.
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