Abstract
1. 1. In the present work, the effect of adenosine agonists and antagonists on apomorphineinduced licking has been studied. 2. 2. Subcutaneous (s.c.) injection of apomorphine (0.125, 0.25 and 0.5 mg/kg) produced dose-dependent licking in rats. 3. 3. Adenosine agonists 5′-N-ethylcarboxamide-adenosine (NECA) and N 6-cyclohexyladenosine (CHA) decreased or increased the apomorphine response respectively. 4. 4. Adenosine antagonists theophylline and 8-phenyltheophylline (8-PT) decreased the response induced by apomorphine. Potentiation of licking induced by CHA was decreased by 8-PT pretreatment. 5. 5. It is concluded that adenosine receptors may be involved in the licking behaviour.
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