Abstract
Stimuli c d 4 9 14 19 -0.06 -0.04 -0.02 0 0.02 0.04 0.06 0.08 G lu ta m at e L e ve l (m M ) 4 9 14 19 -0.06 -0.04 -0.02 0 0.02 0.04 0.06 0.08 G lu ta m at e L e ve l (m M ) Evoked Gamma-Band Activity (μV) Object Stimuli 10 11 12 13 14 15 16 17 Stimulus Glutamate level Object Abstract b Combining measures of electrophysiology and neurotransmitters in humans? • Different ways of investigating possible relationship – Use measures of EEG/MEG and MRspectroscopy to measure neurotransmitter concentration (Lally et al., 2014) – Using drugs that block or enhance specific transmitters, for example ketamine, a NMDA antagonists Methods • The influence of ketamine on WM using EEG. Participants were randomised to receive an intravenous infusion of placebo (0.9% normal saline) or Ketamine. •Ketamine was administered to achieve a dose of 100ng/ml
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