Abstract
Reports on vocal cord palsy in diabetic patients are increasing in the literature but few reports deal with the morphology of the RLN in experimental models of diabetes. Also, effects of acute insulin treatment in experimental diabetes are also rarely reported. In the present study, male Wistar rats received a single intravenous streptozotocin (STZ) injection in order to induce diabetes (N=7) while control rats received vehicle (N=9). STZ + insulin animals (N=8) received a daily subcutaneous insulin injection three days after STZ injection. On the 15th day after STZ or vehicle injections, rats were anesthetized for arterial pressure (AP) and heart rate (HR) recordings, prior to RLN removal. Proximal and distal segments of the right and left RLN were prepared for light microscopy morphometry, carried out with the aid of a computer software. Myelinated fiber morphometry showed a tendency (P = 0.07) towards a significant difference in the fiber and axon diameter between control and STZ+insulin, tending to be larger in the control group. The opposite tendency (p=0.07) was observed for the G ratio values, being larger on STZ+insulin group compared to control. Our results show that acute treatment with insulin affects negatively the size of myelinated fibers and axons in the recurrent laryngeal nerve.Support: FAPESP, CNPq, CAPES and FAEPA
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