Abstract
AbstractEffects of acute, 4-wk inhalation of respirable coal fly ash aerosol on the pulmonary metabolic defense capability were studied in rats. The fly ash was collected from the baghouse of a small, underfeeder-type coal combustor used for greenhouse heating. Effects were studied by measuring alterations in activities of specific antioxidant and drug metabolizing enzymes in rat lungs. Fly ash exposure for 6 hlday and 5 dayslwk during 4 wk to 10, 30, or 700 mg/m3 significantly increased the cytosolic protein level and the activities of glutathione peroxidase and glucose-6-phosphate dehydrogenase. Fly ash also enhanced the microsomal protein level, although the total cytochrome P-450 content was not changed. Fly ash caused a dual effect on cytochrome P-450 isoenzyme-related substrate metabolism. The O-deethylation of ethoxyresorufin was increased, whereas O-dearylation of benzoxyresorufin was decreased. The above results indicate that subacute inhalation of respirable coal fly ash aerosol in rats is able ...
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