Effects of Acute Ingestion of Native Banana Starch on Glycemic Response Evaluated by Continuous Glucose Monitoring in Obese and Lean Subjects.

Guadalupe Jiménez-Domínguez,Isela Juárez-Rojop,Carlos García-Vázquez,Deysi Ble-Castillo,Viridiana Olvera-Hernández,Bedelia Pérez-Pimienta,María Aparicio-Trápala,José Mendez,Juan Diaz-Zagoya,Jorge Ble-Castillo,Carlos Tovilla-Zárate

doi:10.3390/ijerph120707491

Abstract

An abnormal glycemic profile, including postprandial glycemia and acute glucose spikes, precedes the onset of overt diabetes in obese subjects. Previous studies have shown the beneficial effects of chronic native banana starch (NBS) supplementation. In this study, we examined the effects of acute ingestion of NBS on glycemic profiles by means of continuous glucose monitoring in obese and lean subjects. In a crossover study, obese and lean subjects consumed beverages containing either 38.3 g of NBS or 38.3 g of digestible corn starch (DCS) twice daily during 4 days. On day 5, a 3-h meal tolerance test (MTT) was performed to evaluate glucose and insulin responses. After 1 week of washout period, treatments were inverted. NBS supplementation reduced the 48-h glycemia AUC in lean, obese, and in the combined group of lean and obese subjects in comparison with DCS. Postprandial glucose and insulin responses at MTT were reduced after NBS in comparison with DCS in all groups. However, no changes were observed in glycemic variability (GV) indexes between groups. In conclusion, acute NBS supplementation improved postprandial glucose and insulin responses in obese and lean subjects during 48 h of everyday life and at MTT. Further research to elucidate the mechanism behind these changes is required.

Highlights

Worldwide, the combined prevalence of overweight and obesity rose by 27.5% for adults and by47.1% for children between 1980 and 2013
Obese subjects exhibited higher BMI values compared with lean subjects
We showed that acute supplementation of native banana starch (NBS) significantly reduces glucose excursions measured by

Summary

Introduction

The combined prevalence of overweight and obesity rose by 27.5% for adults and by47.1% for children between 1980 and 2013. It is known that in addition to postprandial hyperglycemia peaks, glycemic variability (GV), understood as upward and downward acute glucose fluctuations abroad a determined range is associated with oxidative stress damage to the cells [4,5,6,7]. These alterations have been linked with the development of diabetes complications and might be associated with a reduction in time of diabetes onset in obese subjects. Resistant starch (RS) is recognized as a dietary fiber that resists digestion in the human small intestine and that reaches partial or complete fermentation in the colon [9]

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