Abstract
The muricidal behavior of spontaneous killer rats was blocked after the first injections of an extract of Cannabis sativa corresponding to 8.8 mg of Δ9-tetrahydrocannabinol. On the contrary, to rats which did not show this behavior spontaneously, the chronic administration of the extract induced mouse-killing behavior; this effect of marihuana was potentiated by starvation which, by itself, did not interfere with the behavior of the non-killer rats. These results tend to support the view that cannabis has a dual action. Suppression of muricidal behavior may occur due to the acute depressant effects of marihuana. Under chronic administration, however, tolerance develops to these effects unmasking hyperemotionality and/or irritability which may induce killing behavior in previously non-killer rats.
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