Abstract
The effects of acute and chronic administration of Δ9-THC, cannabis extract and control solution on the behavior of rats repeatedly exposed to an open-field arena have been studied. After the first dose both Δ9-THC and cannabis extract significantly decreased defecation, grooming and rearing; ambulation was not affected. After 20 injections of both marihuana compounds the rats showed values for defecation, grooming and rearing near to those obtained during the predrug phase; control rats, however, showed a significant decrease in these parameters indicating habituation to the open-field. The results are discussed in terms of effects of marihuana on emotional behavior of rats.
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