Abstract
Objective To probe the effect of electroacupuncture (EA) at Shenshu (BL 23) on morphine withdrawal syndrome and the mechanism. Methods Morphine dependence was induced in the rat by subcutaneous injection of morphine, and the acute withdrawal syndrome was precipitated b y intraperitoneal administration of naloxone. The rats were pretreated with 100 H z EA at Shenshu (BL 23) for one hour before the naloxone challenge. Withdrawal scores were calculated, and c-fos levels were detected by immunocytochemical meth od. Results EA at Shenshu (BL 23) could obviously inhibit withdrawal syndrome, decreased expression of c-fos in the PAG, paraventricular hypothalamus nucleus, lateral hypothalamic area and hypocampus while EA increase c-fos positive neurons in the amygdula and core of nucleus accumbens. Conclu sion EA at Shenshu (BL 23) can effectively inhibit morphine withdrawal s yndrome and many central nucleus groups are involved in the inhibition of EA on opioid m edicine dependence.
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