Abstract
1. The incorporation of [ 3H]uridine into RNA and RNA precursor fractions of chick embryo cells was investigated. 2. Actinomycin D inhibited the incorporation of [ 3H]uridine into RNA and also led to a decreased rate of incorporation into the nucleic acid precursor fraction. 3. 2-Mercapto-1-(β-4-pyridethyl)benzimidazole competitively inhibited the incorporation of [ 3H]uridine into the precursor fraction and consequently decreased the apparent rate of nucleic acid synthesis. 4. The mechanisms of [ 3H]uridine incorporation into chick cells and of these inhibitions are discussed.
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