Abstract
Cyclophosphamide (CP) is a well-known chemotherapeutic agent used to treat many gynecological cancers as well as autoimmune disorders such as lupus and rheumatoid arthritis. CP is metabolized in the liver to give two stable toxic compound one of which is Acrolein, a highly electrophilic, α, β-unsaturated aldehyde, which ultimately collects and gets excreted through the bladder. Mesna (sodium-2-mercaptoethane sulfonate) is primarily used to prevent nephrotoxicity by binding to acrolein. Our previous has established that CP, its major metabolite: acrolein and mesna affect female fertility through deterioration of oocyte quality by generation of reactive oxygen species (ROS).
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