Abstract
Acetylsalicylic acid has an antiplatelet effect and is used in long-term at low doses to prevent heart attacks, strokes and blood clot. The aim of the study was to investigate whether ASA could have pathological effects on heart tissues. Rats divided into three groups: Group 1 were given distilled water as controls, group 2 treated with ASA (500mg/Kg/d) by gastric gavage for 7 days and group 3 were received 500mg/Kg/d of ASA once daily for 7 days, then ASA was stopped for this group after 7 days and completed for a month. The histological sectioning of the control group was performed after 7 days and one month later, the second group after 7 days, and the third group after one month, then the result was observed. Histological examination of heart sections showed focal hyalinization in association with congestion in the myocardial blood vessels in rats treated with ASA for 7 days. While, sections of group three, revealed focal few inflammatory cells infiltration associated. It was concluded that, acetylsalicylic acid should be used only in limited amounts for limited periods as its signs of toxicity appeared even with its therapeutic dose.
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