Abstract
Studies have been carried out to correlate oxidation of reduced glutathione and hemoglobin with changes in intracellular organic phosphates following in vitro incubation of erythrocytes with acetylphenylhydrazine. An 8-h incubation of erythrocytes with acetylphenylhydrazine caused a marked increase in the rate of conversion of adenine nucleotides to hypoxanthine. Possible mechanisms for the increased breakdown of adenine nucleotides of erythrocytes in the presence of acetylphenylhydrazine are discussed. In addition, anion exchange analyses of erythrocytes of subjects with various types of anemia indicated the presence of other abnormalities. Four subjects had high levels in erythrocytes of cytidine and deoxycytidine-containing nucleotides and three subjects had high levels of guanosine diphosphate mannose. Erythrocytes of four subjects had elevated levels of adenosine monophosphate, adenosine diphosphate and hexose diphosphate. The possible significance of these results is discussed.
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