Abstract
Abstract This study assessed the impacts of an ointment on treatment efficacy, side effects and global tolerance of most common genital diseases. This observational study enrolled symptomatic patients with LS and psoriasis under maintenance therapy (topical steroids); patients with condyloma acuminata treated with liquid nitrogen and/or imiquimod; patients suffering from vulvodynia under multidisciplinary treatment. The tested ointment was added to the usual treatment. Subjective and objective clinical scores, tolerance and Dermatology Life Quality Index (DLQI) were evaluated. One hundred patients completed the study: 26 LS, 6 psoriasis, 52 CA and 16 vulvodynia. There were significant reductions in global symptom and clinical scores for LS (−80.61% and −59.20%, respectively, mean follow-up 66 days) and psoriasis (−82.88% and −82.80%, respectively, mean follow-up of 51 days). The DLQI decreased by 40.17% for LS and 76.92% for psoriasis. The use of ointment resulted in low post-treatment scores for CA (Symptom score: 1.92/maximum 50, clinical score: 2.46/24 maximum, mean follow-up of 17 days). Tolerance was good for all except two patients (one CA, one vulvodynia). Our results indicated the daily applications of an ointment improved treatments for lichen sclerosus, psoriasis (symptoms, clinical signs and quality of life) and for condyloma acuminata (reduced healing time) and was well tolerated during vulvodynia.
Highlights
Genital skin is subject to various irritant factors (Czuczwar et al, 2016)
Nineteen of these patients were lost to follow-up (8 Lichen sclerosus (LS), 3 psoriasis, 4 condyloma acuminata (CA), 4 vulvodynia) and six had a deviation from the study protocol
We studied the effects of treatment on three major symptoms (from GSS, pruritus, burning sensations, dyspareunia (Borghi et al, 2015, 2018)) and added pain, dryness sensation, and discom fort, which are frequently cited by patients
Summary
Genital skin is subject to various irritant factors (Czuczwar et al, 2016). Emollients are important moisturising agents that play an integral part in the treatment of skin disorders. They act by producing an occlusive film on the skin and prevent water loss. Best practice generally advises the use of emollients after the cleansing routine when the skin has a high water—allowing at least 30 minutes to one hour between topical medications, which prevents dilution and the unknown effects on the stability and absorption of the medications (usually topical steroids; Lawton & Littlewood, 2006). External genital diseases may benefit from the addition of skin care with an emollient to medical treatment. Very few studies of this approach have been published
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