Effects of a toothpaste containing 0.3% triclosan in the maintenance phase of peri-implantitis treatment: 2-Year randomized clinical trial.

Abstract

To evaluate the effects of a toothpaste containing 0.3% triclosan in volunteers that have been treated for peri-implantitis and were enrolled in a maintenance program. Subjects presenting at least one implant with peri-implantitis were selected. They received anti-infective surgical therapy, and sixty days post-surgery (baseline) were randomized into two groups, brushing twice/day for 2years (a) with a toothpaste containing 0.3% triclosan+2.0% PVM/MA copolymer (GantrezTM )+1,450ppm fluoride (test) or (b) with a toothpaste containing 1,450ppm fluoride (control). They received clinical and microbiological monitoring at baseline, 3, 6, 12, 18, and 24months, and professional maintenance every 3months. A total of 102 subjects were enrolled (test: 48; control: 54). The control group showed loss of clinical attachment (CA) around treated implants over the course of the study (p<0.05), while the test group was stable for this parameter. The difference between groups (0.55mm) for CA change between baseline and 24months (primary outcome variable) was statistically significant (p<0.05). Red complex pathogens were only reduced in the test group at 24months. The implants with no history of peri-implantitis in the test group had a significant reduction in the percentage of sites with bleeding on probing and in mean probing depth, throughout the study (p<0.05). This improvement was not observed in the control group. A toothpaste containing 0.3% triclosan was more effective than a toothpaste without triclosan in maintaining a healthy peri-implant environment around treated implants and implants with no history of peri-implantitis during a 2-year maintenance program (ClinicalTrials.govNCT03191721).