Abstract
Objective To study the antidepressant effect of a polypeptide drugs—XMT. Methods Using the suspension test, forced swim test,5-hydroxy-L-tryptophan( 5-HTP) induced head twitch response test and yohimbine induced lethality test in mice,the antidepressant effect and the possible mechanisms of XMT were measured. Results In the tail suspension test,repeated administration( 0. 3-10 mg/kg,sc) with XMT for 5 d reduced the immobility time in mice( P 0. 05 vs the normal saline control). XMT( 0. 3-5. 0 mg / kg,sc for 5 d) can reduced the immobility time in the forced swim test in mice( P 0. 05 vs the normal saline control),while there was no central stimulated effect during the effective doses( 0. 3-5. 0 mg / kg). Furthermore,XMT in repeated doses( 5. 0 and 1. 0 mg / kg,sc for 5 d) decreased the 5-HTP induced head twitch response in mice( P 0. 01,P 0. 05 vs the normal saline control), while it had no effect on the yohimbine toxicity( P 0. 05 vs the normal saline control). Conclusion XMT has antidepressant effect which may be related to the property of inhibition the 5-HT2 receptor,etc.
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