Effects of a Personalized VLCKD on Body Composition and Resting Energy Expenditure in the Reversal of Diabetes to Prevent Complications.

Renzo Renzo,De Lorenzo De Lorenzo,Romano Romano,Gualtieri Gualtieri,Lou De Santis Lou De Santis,Marchetti Marchetti,Belcastro Belcastro,Perrone Perrone

doi:10.3390/nu11071526

Renzo Renzo, De Lorenzo De Lorenzo + Show 6 more

Open Access

https://doi.org/10.3390/nu11071526

Copy DOI

Journal: Nutrients	Publication Date: Jul 4, 2019
Citations: 34	License type: CC BY 4.0

Affiliation: University of Rome Tor Vergata

Abstract

The reversion of diabetes and the treatment of long-term obesity are difficult challenges. The failure mechanisms of rapid weight loss are mainly related to the wasting of lean mass. This single-arm study aims to evaluate the effects of a very low-calorie ketogenic diet (VLCKD) on body composition and resting energy expenditure in the short term reversal of diabetes mellitus Type 2. For eight weeks, subjects were administered a personalized VLCKD with protein intake based on lean mass and synthetic amino acidic protein supplementation. Each subject was assessed by anthropometry, Dual-energy X-ray Absorptiometry(DXA), bioimpedentiometric analysis (BIA), indirect calorimetry, and biochemical analysis. The main findings were the saving of lean mass, the reduction of abdominal fat mass, restored metabolic flexibility, the maintenance of resting energy expenditure, and the reversion of diabetes. These results highlight how the application of preventive, predictive, personalized, and participative medicine to nutrition may be promising for the prevention of diabetes and enhancement of obesity treatment.

Highlights

Obesity and poor nutrition are the main causes of the increase in chronic degenerative diseases that can be observed globally [1]
One of the main diseases related to obesity is diabetes mellitus type 2 (DMT2)
In the process of DMT2 reversion, the main results obtained from this exploratory study on body composition (BC)

Summary

Introduction

Obesity and poor nutrition are the main causes of the increase in chronic degenerative diseases that can be observed globally [1]. One of the main diseases related to obesity is diabetes mellitus type 2 (DMT2). The International Diabetes Federation reports that 382 million people worldwide suffer from DMT2 and that 352 million are at risk of developing it [3]. Limiting the incidence of diabetes and reducing the prevalence of subjects suffering from prediabetes and obesity would lead to a considerable improvement in the quality of life of patients and an economic savings governments. Obesity is a cause of diabetes, the prescription of DMT2 drugs is significantly higher than those for anti-obesity, when it would be enough to treat obesity to reduce DMT2 onset [4]. Even more paradoxical is that personalized dietary interventions and lifestyle changes would be enough to cure obesity [5,6]

Objectives

Methods

Conclusion