Effects of a nutritional liquid supplement designed for diabetes mellitus on postprandial glucose and pregnancy outcomes in patients with gestational diabetes mellitus

Abstract

To explore the effects of nutritional liquid supplement designed for diabetes mellitus on postprandial glucose state and pregnancy outcomes in patients with gestational diabetes mellitus (GDM). A total of 69 cases of pregnant GDM women at Department of Obstetrics & Gynecology, First Affiliated Hospital, Chongqing Medical University from October 2011 to January 2012 were randomized into the intervention and control groups. But only 31 cases in intervention group finished the study versus 29 cases in control group. The inter-group differences were analyzed for general clinical profiles before intervention, 2-hour postprandial blood glucose levels and pregnancy outcomes, etc. The General Linear Model Repeated Measures process was used to analyze the variance of 2-hour postprandial blood glucose data. And the Mauchy's test of sphericity was employed to determine the correlation. (1) No significant difference in general clinical profiles before intervention between intervention and control groups (P > 0.05). (2) The mean values of 2-hour postprandial blood glucose were as follows: intervention group (mmol/L) : 6.2 ± 0.7(1w), 5.9 ± 0.5(2w), 5.7 ± 0.5(3w), 5.8 ± 0.6 (4w), 5.7 ± 0.5(5w), 5.7 ± 0.4(6w), 5.9 ± 0.3(7w), 6.0 ± 0.4(8w), 6.0 ± 0.5(9w); control group: 6.7 ± 0.3 (1w), 6.2 ± 0.4(2w), 6.2 ± 0.5(3w), 6.2 ± 0.4(4w), 6.1 ± 0.4(5w), 6.0 ± 0.3 (6w), 5.8 ± 0.4 (7w), 6.1 ± 0.4 (8w), 6.1 ± 0.4(9w). The results of Mauchy's test of sphericity indicated that the blood glucose level of the intervention group was significantly lower than that of the control group (P < 0.01). (3) The incidence of premature rupture of membranes and polyhydramnios, rate of neonatal pneumonia, weight of newborn and pregnancy women and level of glycosylated hemoglobin in intervention group were significantly lower than those in control group (P < 0.05). Compared with common diet, after using nutritional supplement, the postprandial blood glucose level is significantly reduced and the pregnancy outcomes also improved in GDM patients.