Effects of a Novel Formulation on Oral Biofilm, pH Buffering, and Gingival Health in Patients with Dry Mouth.

Thair Takesh,Afarin Anbarani,Miracle Vania Firmalino,Petra Wilder-Smith,Delaney Islip,Jessica Ho

doi:10.1155/2018/2748274

Abstract

Goal To identify in patients with dry mouth the effects of a novel test agent (Oral Essentials Hydrating Formula Mouthwash, Beverly Hills, CA) versus a control agent (Biotène Dry Mouth Oral Rinse, GlaxoSmithKline Consumer Healthcare L.P., Moon Township, PA, USA) versus no treatment on dry mouth, plaque, salivary pH and buffering capacity, gingival health, and tooth sensitivity. Materials and Methods In this cross-over study, ten subjects with dry mouth used test and control dry mouth interventions, as well as no dry mouth intervention in randomized sequence. Plaque Index, Gingival Index, Sulcus Bleeding Index, Plaque staining, and photographs were recorded at baseline and end of each study arm. Salivary volume, pH, and buffering capacity were also recorded at these time points. Additionally, subjects completed a questionnaire for dry mouth and dentinal sensitivity at each visit. Results Reductions in plaque presence and clinical indices were similar after use of test or control products (p < 0.05). Saliva volume and pH buffering improved significantly after use of test and control products (p < 0.05). Conclusions The effects of a novel dry mouth intervention are similar to those of an existing OTC remedy and are significantly better than no intervention.

Highlights

With a reported prevalence of 5% to 46% [1], dry mouth has many negative sequellae [2, 3]
As saliva lubricates and cleanses the mouth, protects teeth through its buffering and remineralizing properties, supports antimicrobial activity and hard tissue remineralization [4], and assists with chewing and speech, adequate salivation is essential to oral health and comfort
All subjects signed an informed consent at the beginning of the study, as well as statement of patient rights and photographic release forms

Summary

Introduction

With a reported prevalence of 5% to 46% [1], dry mouth has many negative sequellae [2, 3]. One study reported persistent dry mouth in 17.5% of the elderly surveyed, with significantly higher prevalence in women [5]. Chronic conditions that can cause dry mouth become more common, and the associated medications can further exacerbate the overall reduction in salivary presence, as well as variations in its biochemical composition and functions [6,7,8,9,10,11,12,13,14,15]. Other causes of dry mouth include head and neck radiotherapy [16], salivary gland disorders [17], diabetes [17], and Sjogren’s syndrome [18]

Methods

Results

Conclusion