Abstract
ObjectiveB6, an analog of curcumin, is a compound isolated from a traditional Chinese medicine Turmeric. In this paper, we aimed to explore the efficacy of B6 on diabetic nephropathy and the related mechanisms.Materials and methodsThe effects of B6 were studied on fast-blood glucose, serum creatinine, urea nitrogen, urine albumen/24 h, pathological changes of main organs, the levels of ACE2 and ACE2 mRNA in the rat model of diabetes induced by streptozotocin.ResultsThe results showed that B6 treatment could reduce serum creatinine, urea nitrogen, urine albumen/24 h, decrease the level of AngII, improve the renal pathological changes in diabetic rats and increase the levels of ACE2 and ACE2 mRNA.ConclusionThese results suggested B6 could protect the renal function of diabetic rats. This study provided scientific basis for the further researches and clinical applications of B6.
Highlights
Diabetic nephropathy (DN) is a common complication due to diabetes and the most common cause of end-stage renal disease (Kanwar et al 2011)
We showed that B6 could reduce the levels of some biochemical indexes, improve the renal pathological changes, enhance the level of ACE2 and prevent renal injury in experimental diabetic rats
There were no significant differences in kidney/body weight ratio in DM group and B6 treatment groups (Table 1)
Summary
Diabetic nephropathy (DN) is a common complication due to diabetes and the most common cause of end-stage renal disease (Kanwar et al 2011). Curcumin (1, 7-bis-(4-hydroxy-3-methoxyphenyl)-1, 6-heptadiene-3, 5-dione) is the main active component of the natural turmeric (Bengmark 2006) It has been extensively demonstrated as a multifunctional agent on cancer, inflammation, cholesterol-lowering and inflammatoryrelated diseases (Di et al 2010; Shu et al 2007; Sun et al 2014). It showed that curcumin could significantly improve the renal functions of streptozotocin-induced diabetic rats. The results showed the bioavailability of gastrointestinal tract in rats was 8.884 ± 0.879% and the plasma half-life was 143.535 ± 48.375 min (Jiang et al 2016)
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