Abstract
Purpose: Tear hyperosmolarity may arise due to evaporation from the exposed ocular surface, in situations of low aqueous tear flow, and/or in response to excessive water evaporation. Increased tear hyperosmolarity may affect ocular surface epithelial cells by initiating an inflammatory response, including an elevated level of pro-inflammatory cytokines and chemokines. The novel silicone hydrogel daily disposable (SiHyDD), kalifilcon A (KA), incorporates osmoprotectants erythritol and glycerol in the material and packaging solution to support ocular surface homeostasis.
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