Abstract
Cold plasma treatment increases the hydrophilicity of the surfaces of implants and may enhance their integration with the surrounding tissues. The implaPrep prototype device from Relyon Plasma generates cold atmospheric plasma via dielectric barrier discharge (DBD). In this study, titanium surfaces were treated with the implaPrep device for 20 s and assessed as a cell culture surface for fibroblasts. One day after seeding, significantly more cells were counted on the surfaces treated with cold plasma than on the untreated control titanium surface. Additionally, the viability assay revealed significantly higher viability on the treated surfaces. Morphological observation of the cells showed certain differences between the treated and untreated titanium surfaces. While conventional plasma devices require compressed gas, such as oxygen or argon, the implaPrep device uses atmospheric air as the gas source. It is, therefore, compact in size and simple to handle, and may provide a safe and convenient tool for treating the surfaces of dental implants, which may further improve the implantation outcome.
Highlights
The failure of implants to achieve good osseointegration within the surrounding bone tissue after implantation is often an important reason for the failure of implant surgery [1].It has always been the research direction for the majority of scholars to improve the success rate of implantation by changing the surface properties of the implant, increasing the biocompatibility between the implant and the surrounding tissue, and reducing the risk of infection after implantation [2–6]
The soft tissue around the implant is composed of epithelial tissue consisting of epithelial cells and connective tissue consisting of fibroblasts
It was found that epithelial cells have migrate along the surfaces of the implant towards the root, while healthy connective tissue can prevent the migration of epithelial cells towards the root
Summary
The failure of implants to achieve good osseointegration within the surrounding bone tissue after implantation is often an important reason for the failure of implant surgery [1]. It has always been the research direction for the majority of scholars to improve the success rate of implantation by changing the surface properties of the implant, increasing the biocompatibility between the implant and the surrounding tissue, and reducing the risk of infection after implantation [2–6]. The soft tissue around the implant is composed of epithelial tissue consisting of epithelial cells and connective tissue consisting of fibroblasts. A good bond between connective tissue and the implant means that fibroblast can adhere and proliferate well on the implant surface. The factors that influence the cell adhesion and proliferation are the surface roughness, surface morphology, surface chemistry, and hydrophilicity [9]
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