Effects of a new laparoscopic surgery for patients with hydrosalpinges on in vitro fertilization embryo transfer

Abstract

A total of 199 patients of infertility caused by occlusion of fallopian tubes who visited Yantai Yuhuangding Hospital, Shandong province, from July 2006 to December 2007 were recruited and divided into three groups, 16 in Group A undergone with a new laparoscopic surgery for hydrosalpinx before in vitro fertilization embrgo transfer (IVF-ET) ,59 in Group B with traditional salpingectomy for hydrosalpinx or ectopic pregnancy prior to IVF-ET,and 124 in Group C without hydrosalpinx and with no interventions for their occluded fallopian tubes, but undergone IVF-ET only as controls. There were no significant difference in number of the antral follicles counted and serum level of estradiol on the day of human chorionic gonadotrupin (HCG) injection between in Group A and C [(8. 6 ±2. 5 ) vs. ( 10. 0± 2. 4), and ( 12 167±2053) vs. (12 278 ±1366) pmol/L, P＞0.05] ,as well as number of mature oocytes retrieved [(13 ±6)vs. and ( 12 ±6), P ＞0. 05]. Higher dose of ovary stimulant agent was used in Groups B, higher than that in Group A and C, but there were no significant difference in Group A and C [( 2325 ± 450 ) vs. ( 2250 ±375) U, P ＞0. 05]. The pregnancy rate was 62.5% in Group A,44. 1% in Group B,39. 5% in Group C.Hydrosalpinx is associated with poor outcomes of IVF-ET. The new methods of laparoscopic fallopian tube resection for patients with hydrosalpinx prior to IVF-ET improves pregnancy rate, but do not impair ovarian reserve and reaction to stimulation, as compared to traditional salpingectomy. Key words: Embryo transfer; Infertility,female