Abstract
Physiological processes, as aerobic metabolism and inflammatory response, generate reactive oxygen species (ROS) that may induce cellular injury when their amount is increased and antioxidant defense mechanisms are overwhelmed. Also, ROS are generated following UV skin irradiation able to deplete the natural antioxidant defenses in the skin. The increase in exposure to UV may lead to photoaging and precancerous skin lesions (actinic keratosis). New antioxidant strategies in the prevention and therapy of skin lesions are urgently needed. In this study, we evaluated the antioxidant efficacy of a recombinant form of human manganese superoxide dismutase able to inhibit reactive oxygen species production in some patients affected by severe photoaging and actinic keratosis.
Highlights
The skin is one of the largest organs of the human body, whose main function is to maintain its own integrity, and acts as a protective barrier against external agents, noxious substances and pathogens [1]
We evaluated the antioxidant efficacy of a recombinant form of human manganese superoxide dismutase able to inhibit reactive oxygen species production in some patients affected by severe photoaging and actinic keratosis
superoxide dismutases (SODs) are involved in antioxidant defense in almost all cells, since they catalyze the dismutation of superoxide radical into hydrogen peroxide, which is subsequently converted to water and oxygen by the enzyme catalase [6]
Summary
The skin is one of the largest organs of the human body, whose main function is to maintain its own integrity, and acts as a protective barrier against external agents, noxious substances and pathogens [1]. SODs are involved in antioxidant defense in almost all cells, since they catalyze the dismutation of superoxide radical into hydrogen peroxide, which is subsequently converted to water and oxygen by the enzyme catalase [6]. This paper focuses on a new form of SOD, extracted from human liposarcoma cells, which showed peculiar characteristics both in vivo and in vitro It exhibits a selective cytotoxic power for cells that over-expressing estrogen receptor sites. This protein, has the same enzymatic activity common to all SODs, but differs structurally and functionally from its corresponding native. It is secreted by LSA cells in the medium, whereas the native MnSOD is synthesized and resides in the mitochondrial matrix [8].
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