Effects of a fully enclosed hollow-fiber centrifugal ultrafiltration technique for laboratory biosafety improvement.

Abstract

Laboratory biosafety has become a core focus in biological analysis, owing to the frequent occurrence of laboratory-acquired infections caused by the leakage of pathogenic microorganisms. For this purpose, the authorsdeveloped a safe pretreatment device combining asealing technique with a direct injection technique. In this study, several bacteria and viruses were used to validate the filtration effect of the invention. Data show that the new device can completely filter bacteria and that the filtration rates for hepatitis B virus and hepatitis C virus reached 94% and 96%, respectively. The results show that the new preparation device can effectively block these pathogens andcan improve biological safety and providepowerful protection for technicians.