Abstract
The complexes [CdCl2(ATHTd)] (1) and [Cd(NO3)2(ATHTd)(H2O)] (2) [ATHTd=N-(2-acetyl-2-thiazoline)-N′-(2-thiazolidin-2-one) azine] have been synthesized and characterized by a variety of physico-chemical techniques. X-ray data indicate that in 1 the coordination geometry around the metal ion can be considered a distorted square pyramid with cadmium(II) cation coordinated to one tridentate ATHTd ligand and two chloride ligands. In the case of 2, the coordination environment around Cd(II) atom approximates to a distorted pentagonal bipyramid with the cadmium atom bonded to one tridentate ATHTd ligand, one water molecule, one monodentate nitrate ligand and one bidentate nitrate ligand. The structure of ATHTd in the complexes presents an amino-2-thiazoline form instead of the iminothiazolidine one observed in free ATHTd. Likewise, the degree of rotation of the thiazoline rings around the C(1)–C(4) and C(6)–N(3) bonds has changed in complexes, which permit the coordination through thiazolinic nitrogen atoms. Besides, we study the phagocytic function in human neutrophils treated with ligand ATHTd, CdCl2, Cd(NO3)2 and complexes 1 and 2. From the obtained results it can be concluded that the complexes 1 and 2 increase the phagocytic capacity of neutrophils with respect to Cd(II) salts and ATHTd.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
