Abstract
Normal rats with chronic cardiac catheters were infused with regular insulin at various doses (0.1 to 0.6 IU/hr). The insulin infusion was limited to the 12 light hours and repeated for 4 consecutive days. Daytime insulin infusion increased the 12 hr cumulative food intake in a dose-dependent fashion. This increase was associated with a compensatory decrease in the subsequent nocturnal intake, so that the 24 hr food intake remained unchanged. Results are discussed in relation to mechanisms involved in the normal circadian rhythms of feeding.
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