Effects of a daily intake of one glass of red wine on biomarkers of antioxidant status, oxidative stress and inflammation in healthy adults

Abstract

Summary Background & aims The objective of this study was to evaluate the effects of a daily intake of one glass red wine (150 mL, 15 g alcohol) on biomarkers of antioxidant status, oxidative stress and inflammation in men and women. Methods Healthy, non-smoking participants (n=94, men and women) were randomized to a red wine group or a control group. Participants in the red wine group consumed 150 mL red wine each day for 3 weeks. Eighty-eight participants completed the study, 31 men and 57 women. We analyzed effects on 33 different biomarkers in blood samples collected at baseline and after intervention. Results No significant effect of red wine consumption was observed in any of the biomarkers studied in men. Minor adverse effects were observed for the plasma antioxidant α-tocopherol, the oxidative stress marker gamma-glutamyl transferase and the anti-inflammatory modulator interleukin-1-receptor antagonist among women. All other biomarkers were unchanged also in women. Conclusions These results indicate that a low daily consumption of red wine does not affect biomarkers of antioxidant status, oxidative stress and inflammation in men. In women, minor adverse effects were observed in a few biomarkers, while most biomarkers were not affected.