Abstract
Sepsis is defined as life-threatening organ dysfunction caused by a dysregulated inflammatory host response to infection, characterised by cytokine release and oxidative stress. Caspase-1 activation and interleukin (IL-1β) release are classical indicators of inflammasome activation. 6-hydroxymelatonin (6OHM) is the main metabolite of melatonin and has potent antioxidant and anti-inflammatory activity. However little is known about its mode of action. The aim of this study was to investigate the effects of 6OHM in a human macrophage model of inflammasome activation under conditions mimicking sepsis.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
