Abstract
The cerebrovascular response to intravenously infused 5-hydroxytryptamine was studied in anaesthetized dogs with the radioactive inert gas elimination technique with external γ-registration. A strong vasoconstrictory effect was found, which could not be abolished by either metysergide or alpha-blockade. The autoregulatory ability was found to be preserved. Even during arterial hypoxia, which has led to vasodilatation serotonin constricts the cerebral vessels.
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