Abstract
The role of thyroid hormone in the con version of AŸ-carotene to vitamin A remains unsettled (Lowe et al., '56; Moore, '57). Moore ('57) in a recent summary con cluded that changes in serum vitamin A associated with changes in thyroid func tion are due to drifts with the metabolic tide. Although this statement has little meaning, it implies that changes in serum vitamin A follow changes in oxygen con sumption. AŸ-Carotene, a precursor of vita min A, is transported in the lipoprotein fraction of serum along with cholesterol. A newly synthesized D-isomer of triiodothyronine (o-T3) causes in euthyroid sub jects a more pronounced effect on serum cholesterol than on oxygen consumption. This compound therefore should be of value in indicating whether changes in serum carotenoids and vitamin A are re lated more closely to changes in oxygen consumption or to changes in serum cho lesterol. In this paper the effects of D-triiodothyronine on serum cholesterol, caroten oids, vitamin A and oxygen consumption in a group of patients with thyroid de ficiency are reported with a note added regarding the effect of D-triiodothyronine on liver storage of vitamin A in rats. METHODS
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