Abstract
2-α-hydroxybenzylbenzimidazole (HBB) at 3 μM strongly inhibited the accumulation of tobacco mosaic virus (TMV) particles over a 5-day-period, when applied soon after inoculation. TMV RNA synthesis was inhibited by up to 50% by HBB when leaf discs in which virus multiplication was well established were treated. HBB also inhibited host DNA, RNA and polyadenylated mRNA synthesis, at least as much as it inhibited TMV RNA synthesis. HBB was unable to prevent accumulation of TMV when applied to whole plants. The possible mode of action of HBB and its use in virus elimination methods are discussed.
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