Abstract
25-Hydroxycholesterol stimulates and progesterone inhibits cholesterol esterification in mouse peritoneal macrophages in a dose-dependent manner. Fluorescence assay showed nonlinear changes in lipid viscosity and protein-lipid interactions in macrophage membranes under the effect of various doses of 25-hydroxycholesterol and progesterone, therefore opposite effects of studied steroids on acyl-CoA:cholesterol acyltransferase activity were not necessarily related to these factors.
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