Abstract
Objective To investigate whether 17-βestradiol can promote regeneration of the remnant liver after semi-hepatectomy with 45 minutes of hepatic ischemia in rats.Methods Male Sprague-Dawley rats were randomly allocated into 3 groups:R group,rats subjected to 50％ hepatectomy alone;R + IR group,rats subjected to 50％ hepatectomy and 45min of hepatic ischemia; E2 + R + IR group,rats administration with 17-βestradiol.The 7d survival rate,serum alanine aminotransferase (ALT) level,liver histology and remnant liver regeneration were then investigated.Results Compared with R + IR group,17-βestradiol significantly improved the 7 d survival rate (80％ vs 20％,P ＜ 0.05),decreased ALT levels (P ＜0.05) and increased the RLW (P ＜0.05).The pathological changes at 12h after reperfusion were milder and the expression of Ki-67,proliferating cell nuclear antigen (PCNA) and Cyclin D1 in the 2d after reperfusion were significantly higher in E2 + R + IR group comparison to those in the R + IR group.Conclusion 17-βestradiol could promote regeneration of the remnant liver after semi-hepatectomy with 45 minutes of hepatic ischemia in rats.The high expression of Cyclin D1 may be one of the reasons. Key words: Estrogen ; Ischemia-reperfusion injury ; Hepatectomy ; Liver transplantation ; Cyclin D1
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
