Abstract
Twenty four hours after i.p. injection of 17β-estradiol (E 2) (500 μg/100 g b.w.) to ovariectomized rats, the hepatocytes [ 3H]-thymidine pulse-labeling index (L.I.) was significantly increased, reaching a value of 4.3 ± 1.6 percent (i.e. much lower than 32.0 ± 2.0 percent 24 h. after partial hepatectomy -PH-). E 2-treatment was followed by an increase in liver content in c-myc transcripts, with a peak at 650 percent basal value at 8 h, very similar to that observed after PH. In contrast, E 2 induced an increase in liver c-Ha-ras expression with a similar time-course evolution but markedly lower amplitude than that seen after PH. These data are consistent with a role of c-myc in proliferative competence i.e. the ability to perform the G0-G1 transition, and with a role of c-ras in further progression of the cells in the cycle.
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