Abstract
Background: To assess the effects of resistance training on circulating irisin concentration in older male adults, and to investigate the association between resistance training induced alteration of irisin and body fat.Methods: Seventeen older adults (mean age is 62.1 years old) were randomized into old control group (male, n = 7), and old training group (male, n = 10). The control group has no any exercise intervention. The resistance training group underwent leg muscle strength and core strength training program two times/wk, 55 min/class for 12 weeks. Before and after the intervention, we evaluated serum irisin level and body composition.Results: Serum irisin level was significantly increased in the resistance training group after the 12 weeks intervention period (P < 0.01), but not in the control group. In the resistance training group, the reduction in whole-body fat percent was negatively correlated with the increase in serum irisin level (r = −0.705, P < 0.05).Conclusion: After the 12 weeks intervention, circulating irisin levels were significantly elevated in the older adults. In summary, serum irisin may be involved in the regulation of body fat in older male adults.
Highlights
Obesity is recognized as a worldwide health concern (Reece et al, 2009; Wang et al, 2011)
It was demonstrated that peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1-a) expression might stimulate an increase in expression of FNDC5 expression in muscle (Bostrom et al, 2012)
We investigated serum irisin levels and body fat percent in control and resistance training groups before and after intervention trial
Summary
Obesity is recognized as a worldwide health concern (Reece et al, 2009; Wang et al, 2011). Fat accumulation induces obesity and increases the risk of type 2 diabetes, hypertension, and cardiovascular diseases (Abraham et al, 2015; Miyamoto-Mikami et al, 2015; Jiang et al, 2016). Irisin could be therapeutic for human metabolic diseases that are improved with exercise intervention (Bostrom et al, 2012). Recent study demonstrated that irisin could up-regulate uncoupling protein 1 (UCP1) gene expression via in white adipose with exercise (Bostrom et al, 2012). To assess the effects of resistance training on circulating irisin concentration in older male adults, and to investigate the association between resistance training induced alteration of irisin and body fat
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