Abstract
The ingestion of Lactobacillus plantarum OLL2712 (OLL2712) cells improved glucose metabolism by suppressing chronic inflammation in mouse models and in a preliminary clinical study. We aimed to clarify the effect of OLL2712 on glucose metabolism and chronic inflammation for healthy adults. Prediabetic adults (n = 130, age range: 20–64 years) were randomly assigned to either the placebo or OLL2712 groups (n = 65 each) and were administered conventional yogurt or yogurt containing more than 5 × 109 heat-treated OLL2712 cells, respectively, daily for 12 weeks. Reduced HbA1c levels after 12 weeks of treatment were observed in both groups compared to those at baseline; however, the 12-week reduction of HbA1c levels was significantly greater in the OLL2712 group than in the placebo group. Increased chronic inflammation marker levels and insulin-resistant index (HOMA-IR) occurred in the placebo group but not in the OLL2712 group. Fasting blood glucose (FBG) levels did not change significantly in both groups; however, in subgroup analyses including participants with higher FBG levels, FBG levels were significantly reduced only in the OLL2712 group compared to baseline. These results suggest that OLL2712 cell ingestion can reduce HbA1c levels and can prevent the aggravation of chronic inflammation and insulin resistance.
Highlights
The prevalence of type-2 diabetes mellitus (T2DM) is prominently increasing worldwide; T2DM deteriorates health and increases medical expenses
The alleviation of chronic inflammation by ingesting lactic acid bacteria (LAB) might prevent insulin resistance and might improve glucose metabolism in the adipose, muscle, and liver tissues [10]; it remained undetermined in previous clinical trials [11,12,13]
Tanaka et al reported that heat-killed Lactobacillus plantarum L-137 improved inflammation and lipid metabolism in overweight healthy adults [12]
Summary
The prevalence of type-2 diabetes mellitus (T2DM) is prominently increasing worldwide; T2DM deteriorates health and increases medical expenses. The alleviation of chronic inflammation by ingesting LAB might prevent insulin resistance and might improve glucose metabolism in the adipose, muscle, and liver tissues [10]; it remained undetermined in previous clinical trials [11,12,13]. Tanaka et al reported that heat-killed Lactobacillus plantarum L-137 improved inflammation and lipid metabolism in overweight healthy adults [12]. They showed that serum levels of aspartate transaminase (AST) and alanine aminotransferase (ALT), biomarkers of hepatic inflammation, were decreased compared to placebo; the reduction in high-sensitivity
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