Abstract
Summary Objectives This study aims to determine the effects of 10 weeks of high intensity interval training besides green tea supplementation on Sirtuin-1 (SIRT1) and Peroxisome Proliferator-Activated Receptor Gamma Co-activator 1-Alpha (PGC-1α) in overweight women. Patients and methods Thirty non-athlete overweight females were randomly assigned into 3 consistent and equal groups including high intensity interval training plus supplement group, high intensity interval training plus placebo, and supplementary group. The training program included 3 sessions of high intensity interval training performed per week for 10 weeks with the intensity of 85–95% HR max. The groups consuming green tea consumed 3 tablets of 500 mg after each main meal for 10 weeks. Venous blood samples at pretest and post-test was used for measuring SIRT1 and PGC-1α. Body mass index, fat percentage, waist-to-hip ratio, and the weight of the participants were assessed before and after intervention. Results The findings showed that 10 weeks of high intensity interval training and green tea supplementation increased levels of SIRT1 (0.23 ± 0.09 to 0.46 ± 0.14) ( P = 0.0001) and PGC-1α (18.81 ± 3.57 to 40.68 ± 7.74) ( P = 0.0001). Further, the regimen decreased weight (70.56 ± 6.19 to 65.38 ± 6.27) ( P = 0.0001), body fat percentage (34.12 ± 1.80 to 27.12 ± 1.45) ( P = 0.0001) and body mass index (27.15 ± 1.47 to 25.31 ± 1.24) ( P = 0.001). These differences were more meaningfully pronounced in the high intensity interval training plus green tea supplement group than the other two groups ( P = 0.001). Conclusion Based on the findings, it can be concluded that the supplementation of green tea with high intensity interval training can significantly reduce weight, body mass index, and undesirable effects of obesity and overweight by increasing the levels of STRT1 and PGC-1α.
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