Abstract
A multigeneration reproduction study was modified to include screening for dominant lethal and teratogenic effects of 1,2-dichloroethane (1,2-DCE) and 1,1,1-trichloroethane (1,1,1-TCE) in drinking solution (Emulphor:deionized water, 1:99, v v ). Male and female ICR Swiss mice received either 1,2-DCE at concentrations of 0, 0.03, 0.09, or 0.29 mg/ml or 1,1,1-TCE at concentrations of 0, 0.58, 1.75, or 5.83 mg/ml. These concentrations were designed to yield daily 1,2-DCE doses of 0, 5, 15, or 50 mg/kg and 1,1,1-TCE doses of 0, 100, 300, or 1,000 mg/kg. No taste aversion was evident for either of the chemicals at any concentration. There appeared to be no dose-dependent effects on fertility, gestation, viability, or lactation indices. Pup survival and weight gain were not adversely affected. 1,2-DCE and 1,1,1-TCE failed to produce significant dominant lethal mutations or terata in either of the two generations tested.
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