Abstract
Cutaneous aging is a complex biological process in which alterations resulting from both innate aging and photodamage are superimposed in the sun-exposed areas of skin. Profound changes have been demonstrated in the dermal connective tissues, among them the elastic fibers that provide physiologic properties of elasticity and resilience to the normal skin. In innate aging there is loss of elastic fibers, while in sun-damaged skin there is massive accumulation of elastotic material that has, however, lost the functional elastic properties. As a result of these changes, combined with other extracellular matrix alterations, skin becomes loose and sags with loss of recoil with advancing age. A bimetal, 0.1% copper–zinc malonate-containing cream (ELASTIderm™, Obagi Medical Products), has recently been shown to improve the appearance of sun-damaged facial skin when applied twice daily for up to 6–8 weeks. This improvement was accompanied by repair of the elastic fiber network. While the precise mechanisms of the...
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