Effects of α-tocopherol on phototoxicity of 8 - methoxypsoralene

Huseyn A Abiyev Huseyn A Abiyev,Khayala R Mammadova Khayala R Mammadova

doi:10.30574/msabp.2021.2.1.0005

Huseyn A Abiyev Huseyn A Abiyev, Khayala R Mammadova Khayala R Mammadova

Open Access

https://doi.org/10.30574/msabp.2021.2.1.0005

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Abstract

Effects of singlet oxygen extinguisher α-tocopherol on combined effects of psoralens and UV on erythema photosensitized with 8-methoxypsoralene were investigated. The leading role of the reactions of photocompounds in induction of PUVA - erythema is considered. A characteristic feature of biologically active psoralens is the high value of quantum output of intercombination conversion, due to which, after absorption of light quants, a significant number of psoralen molecules are formed in a triplet excited state. Psoralen derivatives differ greatly in their ability to photosensitize the skin. In the example of 8-psoralens, a correlation was found between the ability to induce erythema by photocompound to double-spiral DNA in vitro. A clear correlation was identified between the ability to photosensitize erythema and form diadducts. Α-tocopherol has been shown to protect the skin from PUVA erythema if presents during irradiation. In the case of application of α-tocopherol after irradiation, the inhibitory effect was not exhibited.

Highlights

Biological objects have sensitivity to light, since light is absorbed by many endogenous chromophores, for example: visual pigments, proteins, nucleic acids
Elucidating the causes of PUVA erythema should help in the treatment of skin diseases and avoid unwanted side effects
In 58 tests, the antioxidant was applied to the skin before irradiation, of which 49 showed significant inhibition of PUVA erythema

Summary

Introduction

Biological objects have sensitivity to light, since light is absorbed by many endogenous chromophores, for example: visual pigments, proteins, nucleic acids. Elucidating the causes of PUVA erythema should help in the treatment of skin diseases and avoid unwanted side effects. There is a view that the cause of PUVA erythema is the photochemical combination of psoralenes to pyrimidine bases of nucleic acids.

Results

Conclusion