Abstract
We studied changes in the contents of nicotinamide co-enzymes (NAD, NADH, NADP, and NADPH) and of ratios of their levels in the crystalline lens, retina, and tissue of the visual neocortex, as well as in the liver and blood, of rabbits subjected to long-lasting light stress (9-h-long sessions of exposure to light of mercury-tungsten lamps, daily, for 23 weeks, spectral range 350-1150 nm, and power flux density 30 mW/cm2). Parallel injections of α-tocopherol acetate and its short-chain analog 2-4-methyl-3-pentenyl-6-acetohydroxy-2,5,7,8-tetramethyl chromane significantly compensated the light-stressinduced negative modifications of levels of reduced forms of nicotinamide co-enzymes in tissues of the rabbit visual analyzer, liver, and blood (especially ratios of NADPH/NADP levels under the action of an analog of vitamin E).
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