Effects of α- and γ-Interferons and Their Combinations with Dimethyl Dipyrazolyl Selenide on Immune Status and Functional State of the Reproductive System in Cows under Adverse Environmental Impact

Abstract

The outcomes of studying the effects of alpha and gamma interferons and their combinations with dimethyl dipyrazolyl selenide on the immune status and the functional state of the reproductive system in cows under the adverse environmental impact are reported. The positive effects of the drugs, especially their combinations on erythropoiesis and immune status, in the animals were determined. They were expressed as increases in the red blood cell counts, the hemoglobin and hematocrit levels, the white blood cell counts, the total immunoglobulin level, the serum bactericidal and lysozyme activities, the phagocytic efficiency, and the relative counts of T lymphocytes along with decreases in the levels of circulating immune complexes. Improving the immune status of the animals under the effects of the immune-modulating drugs resulted in reducing parturient pathology and postpartum complications, providing the beneficial effects on the functional state of their reproductive system. The cows treated with interferons and their combinations with dimethyl dipyrazolyl selenide had a shorter calving to conception interval and lower insemination indices, while their fertility rates were higher than that in the untreated control animals.