Abstract
The present study investigated the effects of α 1-adrenoceptors and muscarinic cholinoceptors on water intake in adult male rats. Intracerebroventricular (i.c.v.) injections were carried out in all experiments after 24-h deprivation of water. After deprivation, the volume of consumed water was measured for 1 h. Administration of pilocarpine, a muscarinic cholinoceptor agonist (0.5–1 μg/rat), and prazosin, the α 1-adrenoceptors antagonist (2 μg/rat), increased, while scopolamine, a muscarinic cholinoceptor antagonist (5–10 μg/rat), and phenylephrine, an α 1-adrenoceptor agonist (30 μg/rat), decreased water intake in rats. The activation of muscarinic cholinoceptors by pilocarpine attenuated the inhibitory effect induced by phenylephrine. Blockade of muscarinic cholinoceptors did not change the phenylephrine-induced response. Pretreatment with prazosin decreased the pilocarpine-induced response. However, pharmacological blockade of muscarinic cholinoceptors by scopolamine decreased the prazosin-induced effect on water intake. It is concluded that muscarinic cholinoceptors and α 1-adrenoceptors may interact on water intake.
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