Abstract
The influences of gliadin on the function of the intestinal mucosa were studied in children with enteral protein intolerances in a prospective study. Group la* CD, n=14, gluten free diet for 1-2 months (m), histol. findings: type II-III according to SHMERLING. Group 1b: n=8, diet for 10-36 m, type I-II. Group II: Cow's milk protein intolerance, n=7, cow's milk free diet for 1-2 m, type II-III. Method: The netto water flux and the absorption and digestion rates of sugars were determined by perfusion of the upper jejunum immediately before and 2 up to 6 and 24 hrs after enteral infusion of gliadin. Result: 24 hrs after gliadin infusion the digestion and absorption rates of carbohydrates decrease only in the patients with time of treatment of 1-2 m whereas there are no effects in the patients with treatment logner than 10 m. The netto water secretion increases immediately after starting the gliadin infusion independent on time of treatment. Conclusion: the data suggests that different cell populations are influenced by gliadin in CD-patients.
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